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KMID : 0923620110110060412
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Immune Network
2011 Volume.11 No. 6 p.412 ~ p.415
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Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
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Park Sun-Im
Im Sun-A
Kim Ki-Hyang
Lee Chong-Kil
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Abstract
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Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2Kb-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
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KEYWORD
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Hypocrellin A, MHC-restricted antigen presentation, Immunomodulator
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